Project Description
Lincomycin hydrochloride
capsules 0,25 g – Capsulae Lyncomycini hydrochloridi 0,25
international nonproprietary name
Lincomycin.
Ref
BP-0075
Pharmacotherapeutic group
Antibiotics. Lincosamides.
Composition of the preparation
1 capsule contains 250 mg of lincomycin.
Pharmacological action
Pharmacodynamics Lincomycin is effective to gram-positive bacteria (staphylococcus, streptococcus, pneumococcus, diphtheria bacillus) and some anaerobes, agents of gas-gangrene and tetanus inclusive. It is also active to mycoplasm. It is ineffective towards gram-negative bacteria, fungi, and virus. It is active against bacteria, in particular, staphylococcus, resistant to antibiotics. The resistance of bacteria to lincomycin is developed slowly. Therapeutic doses of the drug act bacteriostatically. The mechanism is related to depression of protein synthesis by bacterial cells. Pharmacokineticsis After oral intake, 20-30% of lincomycin dose is absorbed. Max.blood concentration is achieved in 2-4 h. It penetrates to various organs and tissues, bone tissue and liver either. It penetrates poorly through hematoenthephalic barrier still hematoencephalic barrier permeability is increased in case of meningitis. It metabolizes in liver. It is renal and feces excreted.
Indications
The drug is administered in septic conditions caused by staphylococcus, streptococcus, in acute and chronic osteomyelitis, pneumonia, skin and smooth tissue purulent infection, erysipelatous inflammation, otitis, and other infections caused by bacteria sensitive to this antibiotic, in particular, infections caused by bacteria resistant to penicillin and other antibiotics as well as in allergy to penicillin. As lincomycin is accumulated in bone tissue, it is one of the most effective drugs in acute and chronic osteomyelitis and other infective injuries of bones and articulations.
Special indication
It is not recommended to administer concurrently muscle relaxants. In long courses control regularly liver and renal function. In case of the development of pseudomembranous colitis cancel the drug and administer vancomycin or bacitracin.
Special warning
Not established
Dosage and method of administration
The drug is administered orally 1-2 h. before or 2-3 h. After meals as food inhibits and decreases the absorption. Single dose in adults is 0.5 g, daily dose is 1.0—1.5 g. daily dose in children is 30-60 mg/kg of body weigh (2-3 intakes with an interval 8-12 h.). The course of treatment is subject to the type and severity of the disease and is 7-14 days (in osteomyelitis 3 weeks and more).
Overdosage
Not established
Safety measures
Not established
Side effects
Lincomycin intake may cause nausea, vomit, diarrhea, painful stomach. In certain cases allergic reaction, leucopenia, thrombocytopenia. Inlongtreatmentpossiblecandidiasis.
Contraindications
Administration of lincomycin hydrochloride is acontraindicated in pregnancy (except vital necessity), and severe hepatic and renal diseases, individual hypersensitivity to the drug, lactation (suspend breast feeding), in infants (under 1 month).
Interactions with other medicinal preparations
It enhances muscle relaxation caused by muscle relaxants. Antidiarrheal agents, chloramphenicol, erythromycin decreases the effect. In combination with narcotic analgesic agents possible respiratory diseases.
The form of release
Capsules 250 mg. 20 capsules in jar, 10 capsules in blister. 2 blistersinpack.