Project Description
Levomycetin
solution (eye drops) 0.25% – Solutio Laevomycetini 0,25% (guttae ophthalmicae)
international nonproprietary name
Chloramphenicol.
Ref
BP-0071
Pharmacotherapeutic group
Antibioticofamphenicol group.
Composition of the preparation
1 ml of sterile solution (eye drops) contains 2.5 mg of levomycetin (chloramphenicol).
Pharmacological action
Pharmacodynamics Levomycetin is antibiotic of vast gamma of action, it is effective against many gram-positive and gram-negative bacteria, Rickettsia, spirochaeta and some other large viruses. The drug is active towards strains resistant to penicillin, streptomycine, sulphanilamides. It is poorly effective towards acid-resistant bacteria, blue pus bacillus, Clostridium and protozoa. Incommondosesitactsbacteriostatically. The mechanism of antibacterial action is related to breakage of protein bacterium synthesis. The drug resistance is developed slowly and usually without cross resistance to other chemio-therapeutic agents. Pharmacokinetics Therapeutic concentration of levomycetin under local intake is revealed in cornea, iris, vitreous body, (no in lens).
Indications
The drug is administered for prevention and treatment of infection eye diseases (conjunctivitis, blepharitis, keratitis).
Special indication
Not established
Special warning
Not established
Dosage and method of administration
The drug is administered as instillation to conjunctival sac 1—2 drops 3—4 times a day.
Overdosage
Not established
Safety measures
Not established
Side effects
Possible allergic reactions.
Contraindications
The drug is contraindicated in depressed hematosis, individual intolerance, skin diseases (psoriasis, eczema, fungi diseases), pregnancy and in infants.
Interactions with other medicinal preparations
To prevent inhibition progression on haemopoiesis it is not recommended to administer concurrently sulphanilamides.To prevent inhibition progression on haemopoiesis it is not recommended to administer concurrently sulphanilamides.
The form of release
0.25% sterile solution of levomycetin (eye drops) invials 10 ml.